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Does grapefruit juice potentiate the effects of alprazolam?

April 26, 2017alprazolam Grapefruit juice potentiate

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Does grapefruit juice potentiate the effects of alprazolam?

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Grapefruit juice has been scientifically proven to potentiate benzodiazepines, including alprazolam. Grapefruit juice inhibits the CYP3A4 enzymes. Inhibition of the CYP3A4 enzymes is what affects the clearance of some drugs. Grapefruit juice could lead to extra sedation. Using grapefruit juice increases the effects and makes the dose more unpredictable. It could be bad if you consume grapefruit juice and alprazolam everyday for a long time. Doing this for a long time could cause a toxic build-up.