Does gonadotropin suppression result in follicular development in premature ovarian failure?
Author(s): Buckler HM, Healy DL, Burger HG Affiliation(s): Prince Henry’s Institute of Medical Research, Monash Medical Centre, Melbourne, Australia. Publication date & source: 1993-06, Gynecol Endocrinol., 7(2):123-8. Publication type: It was hypothesized that premature ovarian failure is a self-perpetuating problem and that suppression of the endogenously raised gonadotropin levels may allow synchronization of follicular growth, so that when the suppression is removed, follicular development may be stimulated by the rapid rise in follicle stimulating hormone (FSH) levels. Microgynon (ethinylestradiol, 30 micrograms and levonorgestrel, 150 micrograms) was administered to eight women with premature ovarian failure for 12 weeks. Serum samples were collected weekly for radioimmunoassay of FSH, luteinizing hormone (LH), estradiol, progesterone and inhibin. On stopping Microgynon, ovarian ultrasonography was carried out, in addition to blood sampling, to monitor any follicular growth. Both
