Does fluoride, as provided by community water fluoridation, inhibit the activity of enzymes in humans?
Fluoride, in the amount provided through optimally fluoridated water, has no effect on human enzyme activity according to generally accepted scientific knowledge. Enzymes are organic compounds which promote chemical change in the body. Generally accepted scientific knowledge has not indicated that optimally fluoridated water has any influence on human enzyme activity. The two primary physiological mechanisms that maintain a low concentration of fluoride ions in body fluids are the rapid excretion of fluoride by the kidneys and the uptake of fluoride by calcified tissues. | Next Set of Questions | Back to Fluoridation | top of page | 24. Can fluoride, as found in optimally fluoridated drinking water, alter immune function or produce allergic reaction (hypersensitivity)? According to generally accepted scientific knowledge, there is no evidence of any adverse effect on specific immunity from fluoridation, nor have there been any confirmed reports of allergic reaction. (Challacombe SJ. Do
