Does Fasciola hepatica infection modify the response of acute hepatitis C virus infection to IFN-alphatreatment?.
World J Gastroenterol 2005 December;11(48):7688-7689 Does Fasciola hepatica infection modify the response of acute hepatitis C virus infection to IFN-alphatreatment? Sahin M, Isler M, Senol A, Demirci M, Ayd1n Z. SDU T1p Fakultesi, Ic Hastal1klar1 BD, Isparta, Turkey. mehmetsahin66@hotmail.com Immunologic response to acute hepatitis C is mainly a Th1 response, whereas fasciolopsiasis is associated with a diverse T-cell response. Interferon-alpha has immunomodulatory effects and enhances Th1 immune response. Fasciola infection could theoretically interfere with the Th1 immune response, even when acquired after an initial response to interferon-alpha treatment for acute hepatitis C virus (HCV) infection.
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