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Does Fasciola hepatica infection modify the response of acute hepatitis C virus infection to IFN-alpha treatment?

April 26, 2017acute fasciola hepatica hepatitis c ifn-alpha infection Response treatment virus

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Does Fasciola hepatica infection modify the response of acute hepatitis C virus infection to IFN-alpha treatment?

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Immunologic response to acute hepatitis C is mainly a Th1 response, whereas fasciolopsiasis is associated with a diverse T-cell response. Interferon-alpha has immunomodulatory effects and enhances Th1 immune response. Fasciola infection could theoretically interfere with the Th1 immune response, even when acquired after an initial response to interferon-alpha treatment for acute hepatitis C virus (HCV) infection. We report here the case of a male patient who acquired Fasciola hepatica infection after an initial response to IFN-alpha therapy with a favorable outcome.