Does every AKU patient develop Dark pigmentation of the skin and if so, which areas are commonly affected?
The onset of pigmentation of the skin is often at similar ages to the pigmentation of the eyes. It can also vary, being more visible in some patients than others. It is often first seen in the ear lobe. We have also seen people with alkaptonuria that have pigmentation of the bridge of the nose, cheeks, hands, and skin overlying tendons.
