Does every AKU patient develop Dark Pigmentation of the eyeball?
Eventually all patients will develop the characteristic pigment changes. There is dark brown to black pigment accumulating in the white part of the eye at the position where tendons of the eye muscles attach to the eyeball. The amount of pigmentation can vary, often it is seen starting in the 4th or 5th decade, however in some individuals it might not be apparent until much later.
