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Does ENBREL affect immunity?

affect enbrel Immunity
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Does ENBREL affect immunity?

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Anti-TNF therapies, including ENBREL, affect host defenses against infections and malignancies since TNF mediates inflammation and modulates cellular immune responses. In a study of 49 RA patients treated with ENBREL, there was no evidence of depression of delayed-type hypersensitivity, depression of immunoglobulin levels, or change in enumeration of effector cell populations. The impact of treatment with ENBREL on the development and course of malignancies, as well as active and/or chronic infections, is not fully understood. The safety and efficacy of ENBREL in patients with immunosuppression of chronic infections have not been evaluated.

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