Does Divalproex sodium reduce agitation in nursing home residents with Alzheimer Disease?
Using a randomized, double-blind, placebo-controlled clinical trial design, Tariot et al (Am J Geriatr Psychiatry. 2005;13(11):9429) assessed the efficacy and safety of divalproex sodium for the treatment of agitation associated with dementia. 153 nursing home residents were recruited with 72% completing the study. A mean dose of 800mg/day was used over the six weeks of the trial. Overall they found no benefit of divalproex sodium for treatment for agitation, leading the authors to conclude that the results do not support findings from previous trials indicating possible benefits. Moderate alcohol consumption reduces risk of ischemic stroke To assess the relationship between alcohol consumption and ischemic stroke, researchers from Manhattan, United States conducted a prospective study of 3,176 participants recruited between 19932001 (Elkind et al, Stroke 2006;37:1319). The mean age of the sample was 69 years. Compared to those who did not drink in the past year, they found moderate dr
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