Does digital vaginal examination using lubricant have an impact on testing of Chlamydia trachomatis by polymerase chain reaction?
Uribasterra P, Creinin MD, Wiesenfeld HC. Sex Trans Dis. 2002;29:112-113. by Matthew Golden, MD Center for AIDS and STD University of Washington Seattle, WA, USA Uribasterra and colleagues conducted a prospective study to assess the potential impact of a non-chlorhexidine containing vaginal lubricant on the sensitivity of PCR testing for Chlamydia trachomatis. Lubricants containing analgesics or phenol have previously been shown to inhibit chlamydial growth on culture [1], so there is some reason to be concerned about this. To my knowledge, the potential impact of lubricants on nucleic acid amplification tests (NAATs) has not been evaluated previously. The study population is composed of a convenience sample of women seen in a Pittsburgh emergency room or ambulatory care clinic. No information is provided about the women or the extent to which they are representative of the population of women from which they were sampled. However, there is little reason to believe that the effects of
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