Does Depo have long term side-effects?
To date no studies have demonstrated any long term side-effects. Recent reports suggest that women who are at risk of developing osteoporosis need to be monitored closely, maintain a calcium-rich diet and do regular weight bearing exercise (low impact aerobics, weight training, walking or running). Smoking has also been shown to increase the risk of osteoporosis. The loss of long-term bone density related to long-term use of Depo appears to be reversed when injections are stopped.