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Does cytochrome P450 play a role in the biotransformation of iloprost?

April 26, 2017cytochrome iloprost p450 play

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Does cytochrome P450 play a role in the biotransformation of iloprost?

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A. In vitro studies reveal that cyctochrome P450-dependent pathways play only a minor role in the metabolism of iloprost. 1.Ventavis (iloprost) Full Prescribing Information. Actelion Pharmaceuticals US, Inc. 2009. 2. Olschewski H, Rohde B, Berhr J et al. Pharmacodynamics and Pharmacokinetics of Inhaled Iloprost, Aerosolized by Three Different Devices, in Severe Pulmonary Hypertension. Chest 2003;124;1294-1304. 3. Olschewski H, Simonneau G, Galie N et al, for the Aerosolized Iloprost Randomized Study Group. Inhaled iloprost for severe pulmonary hypertension. N Engl J Med. 2002;347:322-329.