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Does COX-2 selectivity explain GI toxicity?

April 26, 2017cox-2 explain GI selectivity toxicity

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Does COX-2 selectivity explain GI toxicity?

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The risk of hospitalization due to peptic ulcer complication is about 0.2% per year in non-users of NSAIDs (Saskatchewan data from 1982-1986).1 The most common presentation is gastrointestinal (GI) hemorrhage. Risk is higher in men than women and increases with age.