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Does Coumadin interact with other drugs, including over-the-counter medications?

April 26, 2017Coumadin drugs interact medications over-the-counter

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Does Coumadin interact with other drugs, including over-the-counter medications?

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A. Many drugs interact with Coumadin. Ask your pharmacist to check any prescription or over-the-counter medication for such interactions. Recently, acetaminophen (Tylenol) was reported to increase the risk of bleeding among patients taking Coumadin. Antibiotics such as Bactrim cause a drastic increase in the INR/PT. You should generally not take any product containing aspirin, unless approved by your doctor.