Does CORINA calculate 3D coordinates of proteins?
In general, CORINA does not have any limitations regarding the number of atoms or bonds of an input structure that should be converted into 3D. However, CORINA has been designed to process small to medium sized organic (typically “drug-like”) molecules. The larger a molecules gets the more the intra-molecular interactions gain in importance influencing the secondary structure of a molecule. CORINA can model these interactions only to a limited extend and, therefore, is not able to correctly predict 3D structures of polymers and biopolymers such as proteins, enzymes or nucleic acids.
