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Does cord blood carry a Graft-Versus-Leukemia effect?

April 26, 2017blood carry Cord graft-versus-leukemia

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Does cord blood carry a Graft-Versus-Leukemia effect?

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Apparently very little, if any. Graft-versus-Tumor effect is known to be correlated with Graft-Versus-Host Disease (GVHD). Both are mediated by T-cells. While the T-cell content of umbilical cord blood is lower than bone marrow, it is not low enough to be the sole factor explaining the lower incidence of GVHD in cord transplants. Apparently the types of T-cells, their maturity, and their activity also differ. This is a frontier of on-going research. References: • Wadlow & Porter (2002) Biology of Blood & Marrow Transplantation vol.