Does context influence the duration of locomotor sensitization to ethanol in female DBA/2J mice?
RATIONALE: Repeated exposure to ethanol produces a progressive increase in locomotor sensitivity, referred to as locomotor sensitization. Locomotor sensitization may persist for some time after termination of repeated drug exposure, and context appears to facilitate expression of the behavioral phenomenon. However, many unanswered questions remain concerning the persistence of and degree to which context influences locomotor sensitization to alcohol (ethanol). OBJECTIVES: The goal of the present work was to determine the duration of locomotor sensitization to ethanol and the degree to which context dependence positively influences the induction, expression, and persistence of the behavioral phenomenon in female DBA/2J mice. MATERIALS AND METHODS: Sensitized (with or without ethanol-paired exposure to the testing chamber) and non-sensitized saline control mice were left undisturbed in their home cages until subsequent ethanol challenge and testing in the locomotor activity testing chamb
