Does Celebrex provide the same benefits as aspirin for cardiovascular prophylaxis?
In clinical trials, Celebrex at single doses up to 800 mg and multiple doses of 600 mg BID for up to 7 days duration (higher than recommended therapeutic doses) had no effect on platelet aggregation and bleeding time. Comparators (naproxen 500 mg two times per day, ibuprofen 800 mg three time per day, diclofenac 75 mg two times per day) significantly reduced platelet aggregation and prolonged bleeding time.Significant upper GI bleeding, at 14 and 22 days after initiation of dosing. Approximately 40% of these 5,285 patients were in studies that required them to be free of ulcers by endoscopy at study entry. Thus it is unclear if this study population is representative of the general population. Prospective, long-term studies required to compare the incidence of serious, clinically significant upper GI adverse events in patients taking Celebrex vs. comparator NSAID products have not been performed.
In clinical trials, Celebrex at single doses up to 800 mg and multiple doses of 600 mg BID for up to 7 days duration (higher than recommended therapeutic doses) had no effect on platelet aggregation and bleeding time. Comparators (naproxen 500 mg two times per day, ibuprofen 800 mg three time per day, diclofenac 75 mg two times per day) significantly reduced platelet aggregation and prolonged bleeding time. Significant upper GI bleeding, at 14 and 22 days after initiation of dosing. Approximately 40% of these 5,285 patients were in studies that required them to be free of ulcers by endoscopy at study entry. Thus it is unclear if this study population is representative of the general population. Prospective, long-term studies required to compare the incidence of serious, clinically significant upper GI adverse events in patients taking Celebrex vs. comparator NSAID products have not been performed.
