Does carbamazepine-induced reduction of plasma haloperidol levels worsen psychotic symptoms?
Seven psychotic patients’ plasma haloperidol levels, determined with gas-liquid chromatography, fell a mean of 60% when carbamazepine treatment was instituted. Two patients’ levels became undetectable, and their symptoms worsened. Haloperidol level monitoring may be required for patients given both haloperidol and carbamazepine.
