Does brain death induce a pro-inflammatory response at the organ level in a porcine model?
GROUND: Organs from brain-dead donors have a poorer prognosis after transplantation than organs from living donors. A possible explanation for this is that brain death might initiate a systemic inflammatory response, elicited by a metabolic stress response or brain ischemia. The aim of this study was to investigate the effect of brain death on the cytokine content in the heart, liver, and kidney. In addition, the metabolic and hemodynamic response caused by brain death was carefully registered. METHODS: Fourteen pigs (35-40 kg) were randomized into two groups (1) eight brain-dead pigs and (2) six pigs only sham operated. Brain death was induced by inflation of an epidurally placed balloon. Blood samples for insulin, glucose, catecholamine, free fatty acids (FAA), and glucagon were obtained during the experimental period of 360 min. At the conclusion of the experiment, biopsies were taken from the heart, liver, and kidney and were analyzed for cytokine mRNA and proteins [tumor necrosis
Related Questions
- What is the human brain model which describes the mechanism of relation between the brain activity level and stressor? What is happened in human brain?
- Does brain death induce a pro-inflammatory response at the organ level in a porcine model?
- What are the pre-requisites for recognizing Brain Death and organ retrieval?
