Does bone marrow suppression affect FLC concentrations?
Bone marrow suppression, either because of bone marrow replacement by tumour or resulting from chemotherapy, leads to a reduction in the concentrations of polyclonal FLCs. Typically, at the time of diagnosis, the alternate FLC is suppressed and there is a grossly distorted κ/λ ratio. κ/λ ratios play an important role in assessing changing FLC concentrations in these patients and may even be useful when the concentrations of the monoclonal FLCs are below normal levels.
