Does an elevated Urine P:C Ratio indicate renal disease?
An elevated Urine P:C Ratio indicates that there is a clinically significant amount of protein in the urine. In order to determine if renal disease is responsible for this urinary protein loss, you must first localize the protein loss to the kidneys by ruling out prerenal and postrenal causes (via a history, PE, CBC, biochemical profile and a complete urinalysis). And because the test is so sensitive, you must rule out transient proteinuria (which can be caused by fever, exercise and changes in temperature) to determine that the proteinuria is persistent.
