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Does Alfaxan® cause histamine release?

April 26, 2017alfaxan® cause histamine release

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Does Alfaxan® cause histamine release?

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No, please see Figures 1 and 2 below for more information8. Normal histamine levels in dogs and cats are <1μmol/L and all the values in Figures 1 and 2 below are below 1μmol/L. Figure 1: Normal histamine levels in dogs and cats are <1µmol/L and all the values in Figures 1 and 2 below are below 1µmol/L. Cats were dosed with Alfaxan® at a number of different doses (5, 10, 20 & 30mg/kg - up to 6 times the recommended clinical dose) and there was no significant rise in blood histamine levels. Figure 2: Blood histamine levels in dogs dosed with 30mg/kg of Alfaxan® as an IV bolus injection. Dogs were dosed with Alfaxan® at 30mg/kg (15X the recommended dose) and there was no significant alteration in their blood histamine levels.