Does adjunctive midazolam reduce recovery agitation after ketamine sedation for pediatric procedures?
Sherwin TS; Green SM; Khan A; Chapman DS; Dannenberg B Department of Emergency Medicine, Loma Linda University Medical Center and Children’s Hospital, Loma Linda, CA 92354, USA. STUDY OBJECTIVE: Despite widespread use of adjunctive benzodiazepines during ketamine sedation, their efficacy in reducing recovery agitation in children has never been studied. We wished to characterize the nature and severity of recovery agitation after ketamine sedation in children treated in the emergency department and to determine whether the addition of adjunctive midazolam reduces the magnitude of such recovery agitation. METHODS: The study was a randomized, double-blind, clinical trial of adjunctive midazolam versus placebo during ketamine sedation. We enrolled 104 children aged 12 months to 15 years (median age, 6 years) at a combined university medical center and children’s hospital. Subjects received either intravenous midazolam (0.05 mg/kg up to 2 mg) or placebo after intravenous administration of
