Does adalimumab work?
Adalimumab had an extensive development programme. By the 31st August 2002, 2,468 people with RA had received the drug in many different countries, with many patients having it for more than one year (total experience 4,870 patient-years). Four randomised double-blind placebo controlled clinical studies which studied at least six months of treatment were used for the application to the authorities. In the DE011 study, adalimumab was used alone (monotherapy), in the ARMADA and DE 019 studies, it was used along with Methotrexate. In the STAR study, it was used with several anti-RA drugs including methotrexate, sulphasalazine, hydroxychloroquine, leflunomide, gold and prednisolone, with sometimes more than one of these drugs being used with adalimumab.
