Does acetaminophen diminish the immune response to a vaccine?
This surfaced as findings in a single study that, in some circumstances, showed a reduced response to some vaccines when acetaminophen was given prophylactically to prevent fever following vaccination. At the time when whole cell pertussis vaccine was still in use, ACIP recommended consideration of prophylactic administration of antipyretics such as acetaminophen to children at higher risk for seizures. This recommendation was specifically linked to preventing febrile seizures. Since then, thinking on this issue has changed. We know that fever is a potential adverse event following vaccination. However a review of data by the American Academy of Pediatrics (AAP) suggests that even when given at the time of fever, antipyretic drugs are not effective in preventing febrile seizures. We are still learning and understanding the mechanism by which febrile seizures occur. Both AAP and ACIP are concerned about the potential overuse of antipyretics and the potential to mask an acute illness. Bo
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