DOES A TYPE II GLUCOCORTICOID RECEPTOR AGONIST INHIBIT PITUITARY RESPONSIVENESS TO GnRH?
Case, Lisa1, Breen, Kellie1, Wagenmaker, Elizabeth1, Young, Elizabeth1, Karsch, Fred1, 1 University of Michigan, Ann Arbor, MI ABSTRACT- There is evidence that glucocorticoids play a key role in stress-induced suppression of reproductive hormone secretion. In ovariectomized ewes, stress-like rises in plasma cortisol reduce LH pulse amplitude by suppressing pituitary responsiveness to GnRH. Three types of receptors are implicated in mediating neuroendocrine responses to glucocorticoids: type I (mineralocorticoid ), type II (glucocorticoid or GR), and membrane-bound receptors that mediate rapid actions. Mediation via the type II GR was implicated by recent findings that a GR antagonist, RU486, reversed the effect of cortisol on pituitary responsiveness to GnRH. RU486 is a non-specific antagonist, however, leaving open the possibility of other mediatory pathways. We sought to confirm this finding using the specific type II GR agonist, dexamethasone, to test the hypothesis that a type II G
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