Does a neuropsychological index of hemispheric lateralization predict onset of upper respiratory tract infectious symptoms?
Abstract: Objectives Past studies demonstrate relationships between hemispheric lateralization (HL) and immunity. However, the relevance of HL–immune relationships to health and illness has rarely been investigated. This study tested whether a neuropsychological index of right-hemispheric lateralization (right-HL) predicts development of upper respiratory tract infectious (URTI) symptoms. Design We used a prospective, matched, case-control design. Methods Initially, 80 URTI symptom free adults underwent neuropsychological assessment including right-HL (picture vs. word recognition), and were then followed-up during 10 weeks for development of URTI symptoms and objective signs of URTI. Participants reporting URTI symptoms (Ill; N=21) were matched on age, gender, and IQ with 21 participants remaining well. Results At baseline, the right-HL index was significantly higher in participants who later became ill (9.9%) compared to well participants (3.9%, p<.05). Health behaviour also predicte