Does 22q11 deletion compromise migration of GABAergic interneurons?
Rationale: Our preliminary evidence suggests that 22q11 deletion disrupts migration of GABAergic neuroblasts. Accordingly, we will determine whether this disruption reflects upstream changes in precursor identity or proliferation, compromised motility, or altered migratory environment. We expect autonomous changes in GABAergic migration as well as alterations in the migratory environment. Specific Aim 3. Does 22q11 deletion alter position and differentiation of GABAergic interneurons? Rationale: GABAergic interneuron gene expression and connectivity is disrupted in schizophrenic patients. This may reflect initial failure of GABAergic neurons to acquire appropriate positions, processes or synapses. Accordingly, we will evaluate position of GABAergic irneurons as well as initial elaboration of dendrites and axons in deleted mice. The earliest generated GABAergic neurons may be mispositioned, and such disruptions may lead to inappropriate processes, connections and function. Our data will
