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Do they simply tether pathway components or do they actively participate in the signaling process?

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Do they simply tether pathway components or do they actively participate in the signaling process?

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The study provides an elegant demonstration that scaffold proteins control the flow of information along signal transduction pathways primarily through tethering mechanisms. By creating a “custom-designed” scaffold, the authors have been able to engineer a synthetic signal transduction pathway with novel input and output specificities.

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