Do the unpleasant gastrointestinal side-effects of metformin preclude its use?
While these effects will occur in a certain proportion of women during the initiation of therapy, drop out rates can be reduced by administering a small dose in the first week or so of treatment. Investigations studying the potential use of other insulin-sensitizing drugs such as glitazone rosiglitazone and D-chiro-inositol (INS-1) are still in the infant stage, but they may prove equally or even more effective than metformin without accompanying side-effects.
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- Do the unpleasant gastrointestinal side-effects of metformin preclude its use?
