Do the results of serum screening provide information other than risk for Down syndrome, trisomy 18 and open neural tube defects?
An unexplained low PAPP-A (≤0.4 MoM) in the first trimester or, in the second trimester, an unexplained elevation of maternal serum AFP (≥2.5 MoM), hCG (≥3.0 MoM) and/or inhibin-A (≥3.0 MoM) or a decreased level of unconjugated estriol (≤0.4 MoM) is associated with an increased frequency of adverse obstetrical outcomes such as pre-eclampsia, intrauterine growth restriction and abruption. Consultation with a maternal fetal medicine specialist or an obstetrician is recommended for these women. Targeted ultrasound assessments (including uterine artery Doppler) can be useful in refining the risks.
An unexplained low PAPP-A (≤ 0.4 MoM) in the first trimester or, in the second trimester, an unexplained elevation of maternal serum AFP (≥ 2.5 MoM), hCG (≥ 3.0 MoM) and/or inhibin-A (≥ 3.0 MoM) or a decreased level of unconjugated estriol (≤ 0.4 MoM) is associated with an increased frequency of adverse obstetrical outcomes such as pre-eclampsia, intrauterine growth restriction and abruption. Consultation with a maternal fetal medicine specialist or an obstetrician is recommended for these women. Targeted ultrasound assessments (including uterine artery Doppler) can be useful in refining the risks.
Related Questions
- Do the results of prenatal screening provide information other than risk for Down syndrome, trisomy 18 and open neural tube defects?
- Do the results of serum screening provide information other than risk for Down syndrome, trisomy 18 and open neural tube defects?
- How do the units reported by the newborn screening laboratory compare to serum results?
