Do T cells discover aberration with FasL?
Major histocompatibility (MHC) molecules display Ags, typically fragments of proteins, on the cell surface. A T cell receptor (TCR) on a T cell, binds the complex comprising an Ag and the MHC molecule that presents the Ag on the exterior of a host cell. The TCRs chemical structure accounts for the selectivity of T cells; each TCR is maximally responsive to one Ag, the T cells cognate Ag, or a very small number of Ags. The MHC molecules of mice are called H‑2 molecules. Laboratory mice have been inbred into immunologically identical strains whose MHC types are indicated by various suffixes, including b, d, and k. Smyth has also published results of cytotoxicity assays against various direct and bystander targets using lymph node populations harvested after repeatedly vaccinating mice against splenocytes from immunologically disparate (allogeneic) mice ( [12] ). In most assays, the T cells (H-2b) killed allogeneic cells (H-2k). The T cells, from a vaccinated hosts lymph nodes, thus saw t
