Do Statins Cause Cancer?
Animal studies show that all statins as well as fibrates can cause benign and malignant tumors of various organs at exposure levels similar to those prescribed for humans. However, I am not aware of any proof that this is due to promoting angiogenesis by VEGF or other effects, although this has been suggested (Med Hypotheses 2002; 58:85-6.) and would appreciate references to support this from anyone. Statins do promote the proliferation of endothelial cells via the protein kinase B pathway (Rev Esp Cardiol 2002 Aug;55(8):838-44) and since this is independent of lipid lowering effects, it has been proposed that this may explain some of their benefits in coronary disease by encouraging vasculogenesis (Nat Med. 2000 Sep;6(9):965-6.) However, it seems doubtful that this effect would be of the magnitude required to support the requirements of rapidly proliferating malignant cells. In addition, the literature is conflicting. Cerivastatin (taken off the market in August, 2001), inhibits endot
