Do Sickle Cell Traits (AS phenotype, with A greater than S, eg A=60%, S=37%) get into Sickle Cell Crisis like those with Sickle Cell Disease (SS, SC, Sb-Thal, etc)?
A 13: No. If someone with ‘Sickle Cell Trait’ is found to develop sudden, severe musculo-skeletal pains like happens with Sickle Cell Anaemia, then the ‘sickle trait diagnosis’ as the cause of the problem is wrong. Look for another diagnosis. I have seen people referred to as ‘Sickle Cell Trait’ merely because the father is Sickle Test Positive, but the mother is not. “How can a person have Sickle Cell Disease when only one parent is a Sickler?”, they ask. The answer is that, if the person has a sickle cell crisis, but the mother is ‘Sickling Negative’, then she will almost certainly be found to be ‘POSITIVE’ for Haemoglobin C or other mutant-haemoglobin gene which, together with the Haemoglobin S gene causes severe Ache/Ache disease like Sickle Cell Anaemia (SS). Read that again, and again: “If someone with ‘Sickle Cell Trait’ is found …” Is that clear? “Sickle Negative” does not mean “Abnormal Haemoglobin Negative”. Say that aloud. “Sickle Negative does not mean Abnormal Haemoglobi
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