Do researchers need to test for the Nnt mutation in their mouse models?
Not unless you have specific scientific-based reasons for ensuring you have a functional Nnt gene. The Nnt mutation does not have adverse effects on the lifespan or integrity of the B6/J mouse. In fact, the B6/J is known for its longevity compared to other inbred strains. Every mouse model, including the B6/J and B6/NJ, is genetically distinct with known phenotypic characteristics that make it useful in a wide variety of research areas.
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