Do post-ingestive effects of salicin or aristolochic acid inhibit consumption during the 48 h exposure period?
In the previous experiment, we could not determine the relative contribution of gustatory versus post-ingestive effects of the salicin and aristolochic acid diets on consumption and weight gain. For instance, the caterpillars could have ingested relatively limited quantities of the aristolochic acid diet over the 48 h exposure period because of a failure to adapt to its aversive taste and/or toxic post-ingestive effects. In this experiment (experiment 3), we examined the specific contribution of the post-ingestive effects of salicin and aristolochic acid on weight gain. To this end, we (i) ablated the three bilateral pairs of chemosensilla that underlie the taste-mediated aversive response to salicin and aristolochic acid (the lateral styloconic, medial styloconic and epipharyngeal sensilla), (ii) exposed the ablated caterpillars to the salicin (157 mmol kg–1) or aristolochic acid (0.38 mmol kg–1) diets or the corresponding control diets (see below) for 48 h, and then (iii) determined
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