Important Notice: Our web hosting provider recently started charging us for additional visits, which was unexpected. In response, we're seeking donations. Depending on the situation, we may explore different monetization options for our Community and Expert Contributors. It's crucial to provide more returns for their expertise and offer more Expert Validated Answers or AI Validated Answers. Learn more about our hosting issue here.

Do patients with MGUS require a bone marrow biopsy?

April 26, 2017biopsy bone marrow mgus Patients require

0

Posted

Do patients with MGUS require a bone marrow biopsy?

1 Answer

0

Posted

J. Singh, A. K. Malani, C. H. Huang, M. Hashmi, S. C. Mathur, C. Stasik and P. Van Veldhuizen KU Medcl Ctr, Kansas City, KS; Heartland Regional Medical Center, St. Joseph, MO; Department of Veterans Affairs Medical Center, Topeka, KS; VA Medical Center, Kansas City, MO; Kansas University Medical Center, Kansas City, KS 8117 Monoclonal gammopathy of undetermined significance (MGUS) increase in prevalence with age and it is associated with risk of progression to plasma cell disorder. According to ASH guidelines, patients (pts) should have a complete blood count (CBC), creatinine, calcium, and a complete bone survey and periodic follow up. There has been no clear-cut guideline regarding the role of bone marrow biopsy in these patients. There is suggestion in the literature that bone marrow aspiration and biopsy is indicated if the M protein is 1.5 g/dL. Hypothesis We hypothesize that the increase in serum immunoglobulin is correlated with an increase in plasma cell in the bone marrow biop