Do patients who have taken phen-fen need antibiotic prophylaxis?
Individuals who have taken the appetite suppressant phen-fen (phentermine and fenfluramine) do not require antibiotic prophylaxis based solely on a history of using this drug combination. The 2007 American Heart Association (AHA) guidelines no longer recommend antibiotic prophylaxis in patients with a number of heart conditions, including mitral valve regurgitation. Patients with cardiac abnormalities should be premedicated according to the current AHA guidelines.