Do oranges and other citrus fruits cause the same interaction as GJ ?
This is an evolving area of research, but new evidence indicates that some related citrus fruits may cause drug interactions in a similar manner to grapefruit. These interactions are believed to be due to a group of chemical compounds that are specific to GJ and certain related citrus fruits. The most important of these chemical compounds is called 6′,7′-dihydroxybergamottin. These interactions are not due to vitamin C or citric acid content. A variety of oranges called ‘seville oranges’ contain 6′,7′-dihydroxybergamottin, and did seem to cause a similar drug interaction to GJ, but these are not used for commercial juice production and are only seen in the marketplace as the main oranges used in marmalade production. Evidence now exists for pummelos (pomelos) to cause similar drug interactions to grapefruit. More exotic grapefruit hybrids such as tangelos, have not been directly studied, and since they are not commonly seen in the marketplace, may never be studied. However, these produ
