Do older patients have an increased sensitivity to pharmacologic therapy then younger patients?
Older patients in general are more sensitive than younger adults to the adverse effects of antidepressant medications. However, to obtain a therapeutic response, older patients require drug concentrations similar to those that generally produce a therapeutic response in younger patients. • Are any class of antidepressants more effective than the others? No single class of antidepressant has been found to be more effective than another in the acute treatment of late-life depression. TCAs, SSRIs, and selective noradrenergic reuptake inhibitors (SNRIs) are all effective. Following the era of TCAs, SSRIs quickly became the preferred agents because of their safety profile: relatively high tolerability, relatively low incidence of adverse events, and lower potential for drug-drug interactions. Be aware, however, that, although members of the SSRI class vary in their side-effect profiles, all have been associated with anxiety, insomnia, sexual dysfunction, weight loss, gastrointestinal side e
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