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Do my peptides need N-terminal acetylation and C-terminal amidation?

April 26, 2017acetylation amidation c-terminal n-terminal peptides

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Do my peptides need N-terminal acetylation and C-terminal amidation?

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These modifications may avoid unnatural charges at the peptide terminals and protect the peptides from degradation resulting from exopeptidases. We suggest having the C-terminal amidation, which make the peptide more closely mimic the charge state in the native protein.