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Do misfolded proteins accumulate with age or senescence?

April 26, 2017accumulate age Proteins senescence

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Do misfolded proteins accumulate with age or senescence?

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2008 New Scholar Award in Aging The production of and degradation of cellular proteins is a tightly regulated process. Regulated protein degradation is critical for many cellular processes such as aging and cell growth. Even under normal conditions, up to 30% of all cell proteins fail to fold properly, and are immediately degraded. Aggregation of misfolded proteins is…