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Do longer duplications present more severe symptoms?

April 26, 2017duplications longer PRESENT severe symptoms

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Do longer duplications present more severe symptoms?

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This doesn’t seem to be the case. Individuals with long duplications of 20 or more genes seem to have relatively similar effects to individuals with shorter duplications of just a few genes. The critical thing seems to be the duplication of the MECP2 gene, hence the name of the syndrome.