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Do KCa channels and carbonic anhydrase play a role in thiazide-induced hyperglycaemia?

April 26, 2017anhydrase carbonic channels hyperglycaemia kca play

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Do KCa channels and carbonic anhydrase play a role in thiazide-induced hyperglycaemia?

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10 Posted

Thiazide diuretics are widely used to treat hypertension, but their use is associated with impaired glucose tolerance. We propose that the diabetogenic action of thiazides may be due to their ability to open calcium-activated potassium (KCa) channels in pancreatic beta-cells.