Do insulin-sensitizing medications improve egg quality in IVF?
The follow-up for women taking insulin-sensitizing agents who subsequently undergo IVF/ET is currently limited. No controlled data exist (yet) that proves whether or not normalization of insulin levels has an important effect on oocyte quality, but some generalizations suggest this may indeed be the case. It does appear that use of metformin may increase the number of mature eggs retrieved. For example, among many diabetics both insulin and glucose are elevated. The incidence of congenital anomalies is well known to be higher in these patients. This means something is adversely affecting development with bad perinatal results. At the gamete (egg) level, similar blocks to normal growth may also exist.
The follow-up for women taking insulin-sensitizing agents who subsequently undergo IVF/ET is currently limited. No controlled data exist (yet) that proves whether or not normalization of insulin levels has an important effect on oocyte quality, but some generalizations suggest this may indeed be the case. It does appear that use of metformin may increase the number of mature eggs retrieved. ” Here’s a link to that whole web page, it has lots of Q’s & A’s regarding PCOS women TTC. http://www.inciid.org/faq.ph-p?cat=infertility101&id=-2- (remove any dashes that may appear. The other punctuation in that URL is supposed to be there though). HTH!
