Do ibuprofen and alcohol together cause liver or kidney damage?
Each of these drugs have their own side effects including liver damage (alcohol), stomach damage (both), kidney damage (ibuprofen). Taking both ibuprofen and alcohol can result in gastritis, or inflammation of the stomach lining, which would lead to stomach pain, low grade blood loss and possibly an ulcer. It is also possible that becoming dehydrated due to alcohol could increase your chance of having kidney damage from ibuprofen, but this is just speculation. The most likely effect would be gastritis. “Liver bleeds” are not a real medical issue, and would not be caused by either medicine alone or in combination.