Do glucosamine and chondroitin work?
The most notable dietary supplements for osteoarthritis are glucosamine and chondroitin sulfate, both found naturally in the body. Glucosamine is an amino sugar that appears to play a role in the formation and repair of cartilage. Chondroitin sulfate is part of a protein that gives cartilage its elasticity. For years, the two dietary supplements have been used to treat osteoarthritis in dogs and horses. More recently they have become popular OA treatments for people. Studies done in Europe have found that people with mild to moderate osteoarthritis who took either supplement reported pain-relief levels similar to those achieved with NSAIDs, although the supplements may take longer to begin working. The 2005 results from the NIH Glucosamine/Chondroitin Arthritis Intervention Trial (GAIT), the first large-scale, multi-center clinical trail testing the short-term (six months) effectiveness of the supplements in reducing knee osteoarthritis pain suggested this: the combined supplements red
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