Do genetic factors account for metabolic age remodeling?
To explore the role of inherited factors in successful ageing it may be useful to identify the genes that contribute to human longevity; thus, alleles pools at polymorphic candidate loci were compared between individuals selected for longevity and younger people from the same race and country. Indeed, if a certain locus affects life expectancy, the gene pool of extremely old individuals should be different from that of younger people because of a slow change in the composition of the genotype pool that takes place as survival selection operates. By means of this approach, significant longevity/allele associations have been found at HLA, ACE, THO and mtDNA. Interestingly enough, a significant age-related change in the genotypic pool has also been observed for ApoB, which is a major apoprotein responsible for total cholesterol metabolism. Conducted study showed that ApoB is protective in the physiological scenario of youth individuals, but then becomes frail in the new physiological scen
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- Do genetic factors account for metabolic age remodeling?
