Do fructose-induced changes in lipid metabolism confer increased cardiovascular risk?
The present study (5) adds an important missing piece to the very complex puzzle of diet-induced influences on the pathogenesis of CVD. However, in light of the large body of data available on links between lipid metabolism and cardiovascular risk, the data presented here fall short of providing a complete understanding of the exact role dietary fructose may play within these extremely complicated and multilayered pathophysiological interplays. The current accepted model of pathogenesis suggests that postprandial hyperlipidemia is a characteristic metabolic abnormality of a number of lifestyle-related conditions that are associated with increased morbidity (such as hypertriglyceridemia, metabolic syndrome, obesity, and type 2 diabetes) and mortality from CVD. The perception that carbohydrate intake and not fat intake has a positive association with CVD has put the spotlight on postprandial lipid metabolism. Fructose, as a preferred substrate for lipogenesis, is known from rodent studie
